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Multiple system atrophy(MSA)is a neurodegenerative disorder of unknown cause.The only case-control study conducted in MSA patients to date suggested a possible contributory genetic component in the pathogenesis of this disorder.The aim of this study was to evaluate a possible overlap between clinically or pathologically well-defined MSA and other conditions with an identified genetic defect causing spinocerebellar degeneration in humans or mutant mice strains.No changes were detected in any of the analyzed genes.Our studies strongly suggest that MSA is an autonomous syndrome distinct from identified genetic causes for spinocerebellar degeneration. |
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