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We describe a 16 year old boy with juvenile metachromatic leukodystrophy who was treated with bone marrow transplantation.Followup over 8 years showed no increase in symptoms,no progression of neurological signs and no neuropsychological deterioration.We conclude that bone marrow transplantation may increase brain levels of arylsulfatase A enough to prevent deterioration in patients with juvenile metachromatic leukodystrophy. |
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