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Two groups of patients were identified,those with brain lesions(WBL)and those with no brain lesions.All initial and subsequently obtained MRIs from the WBL group were analyzed and tallied for number,size,and location of lesions over serial studies.Of the nine patients WBL,lesions were in hemispheres in 19 patients,and in the brainstem and the cerebellum in 10 patients each,respectively.Lesions were located in the cerebellum and globus pallidus most often(87 of 129 lesions).Of the patients WBL having serial studies,a total of 97 lesions equaling 197 units(mean,2.03 units per lesion)were identified at initial study.Follow-up evaluation(interval, 0.5-4.5 years;mean 2.3 years)showed a decrease in both total number of lesions(68[-29%])and size(132 units;mean,1.86 units per lesion[-33%]). Importantly,brain stem lesions increased in both number(+36%)and size(+6. 4%)over the same intervals in 7 out of 13 patients WBL studied serially, whereas hemispheric and cerebellar lesions were more evanescent.High- signal T2 lesions on MRI in patients with NF-1 evolve over time.The evolution of the NF-1 lesion is region specific and may relate to preferential region-specific effects of the NF-1 gene product. |
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globus pallidus,lesion of
globus pallidus,lesion of,bilateral
MRI
MRI,abnormal
MRI,disappearing lesion on
MRI,high signal foci on
MRI,high signal intensity of basal ganglia
MRI,serial
neurofibromatosis 1
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