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Stroke in Children and Sickle-Cell Disease, Baltimore-Washington Cooperative Young Stroke Study
Neurol 51:169-176, Earley,C.J.,et al, 1998
See this aricle in Pubmed

Article Abstract
Eighteen children with ischemic infarction and 17 with intracerebral hemorrhage were identified.The most common cause of ischemic stroke was sickle=cell disease,followed by vasculopathic and indeterminate causes. Causes of intracerebral hemorrhages were arteriovenous malformation, hematologic,vasculopathy,surgical complication,coagulopathy,and indeterminate.The overall incidence of childhood stroke was 1.29 per 100, 000 per year,with ischemic stroke occurring at a rate of 0.48 per 100,000 and intracerebral hemorrhage occurring at a rate of 0.71 per 100,000.The incidence of stroke among children with sickle-cell disease was estimated to be 0.28%or 285 per 100,000 per year.Sickle-cell disease plays a disproportionately high role in childhood stroke when a biracial population is surveyed.
 
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