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The estimated age of PSP symptoms onset depends critically on how symptoms onset is defined,with estimates differing by as much as 1.5 years.Men and women were represented equally(51.6%versus 48.4%)in the living sample,but men formed 61.8%of the deceased sample.Men were diagnosed later than women (37.0 versus 47.6 months).Motor and visual symptoms appeared first, followed by emotional and personality problems,cognitive impairment,and sleep changes.Whereas motor symptoms eventually affected almost every patient,emotional/personality and cognitive symptoms did not.The early onset,presence of falls,slowness,and inability to move eyes downward early in the development of the disease predicted survival time.PSP is a rapidly progressive disease dominated by motor symptoms,and is affects men more frequently than woman. |
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