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Genetic Studies on Chromosome 12 in Late-Onset Alzheimer Disease JAMA 280:619-622, 6521998., Wu,W.S.,et al, 1998 See this aricle in Pubmed Article Abstract Although linkage analyses confirmed the presence of a genetic susceptibility factor at the APOE locus in these families with late-onset AD,we were unable to confirm the presence of a locus close to the marker D12S1042.A moderate lod score(l.91)was found near D12S98 close to the a2- macroglobulin locus in the affected pairs in which both members did not possess an APOE e4 allele.APOE remains the only locus established to be a risk factor for late-onset AD.We were unable to confirm that a locus on chromosome 12p11-12 has a major effect on risk for late-onset AD,although an effect smaller than that for APOE cannot be excluded.

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(click to filter results - removes previous filter) Alzheimer's disease Alzheimer's disease,familial Alzheimer's disease,familial,late onset chromosomal abnormality chromosome 12 dementia dementia,familial familial gene genetic neurologic disorders

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