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Early Neurologic Complications Following Allogeneic Bone Marrow Transplant for Leukemia, a Prospective Study
Neurol 50:1441-1445, Antonini,G.,et al, 1998
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Article Abstract
Sixty-four patients(56%)had neurologic complications.Sixteen developed more than one complication.Twenty-seven patients(25%)had major neurologic complications:metabolic encephalopathy(8),seizures(8),psychiatric symptoms (3),cerebral hemorrhage(1),cerebral abscess(1),leukemic meningitis(1), peripheral neuropathies(1)and myopathies(2).Forty patients(35%)had minor complications including headache(16)and tremor(31).Major neurologic complications occurred after engraftment in most patients.Metabolic encephalopathy correlated with graft vs host disease(GvHD).Seven percent of patients had generalized seizures that occurred without signs of structural cerebral lesions.Probability of survival at day 90 was lower in patients with than in those without any major central nervous system complications.Neurologic complications are frequent during the first three months following BMT and affect patient survival.Drug neurotoxicity and acute GvHD are the main factors influencing their occurrence.
 
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abscess,intracerebral
bone marrow transplantation
central nervous system,infection of
chronic graft versus host disease
encephalopathy
encephalopathy,metabolic
iatrogenic neurologic disorders
immunosuppression
intracerebral hemorrhage
leukemia
leukemia,neurologic findings assoc.with
life expectancy
meningitis
meningitis,leukemic
myopathy
neuropathy
neutropenia
organ transplantation
prognosis
psychiatric problems in neurologic disorders
review article
seizure

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