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Clinical Usefulness of Magnetic Resonance Imaging in Multiple System Atrophy JNNP 65:65-71, Schrag,A.,et al, 1998 See this aricle in Pubmed Article Abstract On both 0.5 and 1.5 T scans the following items had high specificity but low sensitivity:putaminal atrophy,a hyperintense putaminal rim,and infratentorial signal change.Finding any infratentorial abnormality gave higher sensitivity but lower specificity.Putaminal isointensity or hypointensity relative to globus pallidus,absolute putaminal hypointensity,and altered size of the olives were not useful discriminators.The overall sensitivity was 73%on 0.5 T and 88%on 1.5 T scans.The specificities of these findings for multiple system atrophy in comparison to idiopathic Parkinson's disease and controls on 0.5 T were 95%and 100%respectively,and on 1.5 T were 93%and 91%respectively.Finding any of the described abnormalities on MRI gave a positive predictive value of 93#on the 0.5 T machine,and 85%on the 1.5 T scanner.

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(click to filter results - removes previous filter) MRI MRI,abnormal multiple system atrophy neurologic disease,diagnoses of Parkinson disease putamen,lesion of spinocerebellar ataxia type 1

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