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In all 70 negative single-dose studies,the triple-dose depicted no additional metastases in terms of the standard of reference.No statistically significant difference was seen between the results of the single-and triple-dose studies.For 10 equivocal single-dose studies,the triple-dose study helped clarify the presence or absence of metastases in 50%of the cases.In 12 patients with a solitary metastasis seen on the single-dose study,the triple-dose study depicted additional metastases in 25%of the cases.In the results of one of the two blinded readers,use of triple-dose contrast led to a statistical difference by decreasing the number of equivocal readings but at the expense of increasing the number of false-positive readings.Routine triple-dose contrast administration in all cases of suspected brain metastasis is not helpful.On the basis of our investigation,we conclude that the use of triple-dose contrast material is beneficial in selected cases with equivocal findings or solitary metastasis,although with the disadvantage of increasing the number of false-positive results. |
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gadolinium
MRI
MRI,abnormal
MRI,contrast enhanced
MRI,contrast enhanced,high dose
MRI,contrast enhanced,triple dose
MRI,false positive
neoplasm,metastatic to CNS
neoplasm,metastatic to CNS-multiple
neoplasm,metastatic to CNS-treatment of
neurologic disease,diagnoses of
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