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Clinical Experience with Diffusion-Weighted MR in Patients with Acute Stroke AJNR 19:1061-1066, Lovblad,K.,et al, 1998 See this aricle in Pubmed Article Abstract Diffusion-weighted MR imaging studies were positive in 133 of 151 cases of infarction(88%sensitivity)and negative in 42 of 43 cases with no infarction(95%specificity).Two cases identified as positive on diffusion- weighted images had nonischemic diagnoses(1.5%false-positive rate). Diffusion-weighted imaging had a positive predictive value of 98.5%and a negative predictive value of 69.5%.Use of T2-weighted sequences as well as diffusion-weighted imaging produced no false-positive findings.Of the negative scans,69.5%corresponded to transient ischemic attacks or infarcts (mostly small brain stem infarcts).When only cases scanned within 6 hours of onset were considered,the sensitivity rose to 94%and the specificity to 100%.Despite bias due to dependence between diffusion-weighted imaging and the final diagnosis,this analysis suggests high sensitivity and specificity for echo-planar diffusion-weighted imaging in the diagnosis of acute cerebral infarction,although negative scans did not rule out an ischemic pathogenesis.

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(click to filter results - removes previous filter) cerebral infarction cerebrovascular accident MRI,cerebrovascular disease MRI,diffusion weighted MRI,early changes in CVA MRI,false negative MRI,false positive review article

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