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We studied 24 patients with idiopathic Parkinson's disease in whom electrodes were implanted bilaterally in the subthalamic nucleus under stereotactic guidance with imaging and electrophysiologic testing of the location. After one year of electrical stimulation of the subthalamic nucleus, the patient's scores for activities of daily living and motor examination scores (Unified Parkinson's Disease Rating Scale parts II and III, respectively) off medication improved by 60 percent (P<0.001). Electrical stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease. The severity of symptoms off medication decreases, and the dose of levodopa can be reduced with a consequent reduction in dyskinesias. |
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activities of daily living disability rating scale,neurological hematoma,intracerebral iatrogenic neurologic disorders intracerebral hemorrhage neurologic complications of,surgery Parkinson disease Parkinson disease,fluctuations in Parkinson disease,surgical treatment of review article spinal cord,blood supply of stereotaxic surgery stimulation,deep brain subthalamic nucleus subthalamic nucleus deep brain stimulation treatment of neurologic disorder tremor,thalamic stimulation for suppression of Unified Parkinson Rating Scale
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