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The Association of the Combination of Sumatriptan and Methysergide in Myocardial Infarction in a Premenopausal Woman Arch Int Med 159:511-513, Liston,H.,et al, 1999 See this aricle in Pubmed Article Abstract Acute myocardial infarction occurred in a 43 year-old premenopausal woman with controlled hypertension and no known coronary artery disease following the use of the antimigraine medications sumatriptan succinate injectable form and methysergide maleate. The use of sumatriptan is contraindicated within 24 hours of using ergotamine or ergotamine-type medications such as methysergide. This contraindication is based on the theoretical possibility of prolonged vasospasm is possibly due to 5-HT supersensitivity mediated by 5-HT1DB receptor activation. Drugs that selectively stimulate the 5-HTD receptors, such as sumatriptan, are potentially hazardous in people with underlying coronary artery disease, and agents with additional agonistic properties at these receptors may potentiate this effect. Physicians should be warned to inquire about prior 24-hour medication use before prescribing antimigraine medication.

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(click to filter results - removes previous filter) adverse drug reaction drug interactions ergotamine migraine migraine,prophylaxis migraine,treatment of myocardial infarction myocardial infarction,acute sumatriptan

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