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Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain,A Randomized Trial JAMA 280:1485-1489,1527, Patchell,R.A.,et al, 1998 See this aricle in Pubmed Article Abstract Recurrence of tumor anywhere in the brain was less frequent in the radiotherapy than in the observation group (9[18%] of 49 vs 32 [70%] of 46. Postoperative radiotherapy prevented brain recurrence at the site of the original metastasis (5[10%] of 49 vs 21 [46%] and at other sites in the brain (7[14%] of 49 vs 17 [37%] of 46. Patients in the radiotherapy group were less likely to die of neurologic causes than patients in the observation group (6[14%]of 43 who died vs 17 [44%] of 39. There was no significant difference between the 2 groups in overall length of survival or the length of time that patients remained functionally independent. Patients with cancer and single metastases to the brain who receive treatment with surgical resection and postoperative radiotherapy have fewer recurrences of cancer in the brain and are less likely to die of neurologic causes than similar patients treated with surgical resection alone.

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(click to filter results - removes previous filter) neoplasm,metastatic to CNS neoplasm,metastatic to CNS-prognosis of neoplasm,metastatic to CNS-recurrent neoplasm,metastatic to CNS-survival neoplasm,metastatic to CNS-treatment of radiation therapy,CNS treatment and complications with treatment of neurologic disorder

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