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Buccal Midazolam and Rectal Diazepam for Treatment of Prolonged Seizures in Childhood and Adolescence:A Randomised Trial Lancet 353:623-626,650, Scott,R.C.,et al, 1999 See this aricle in Pubmed Article Abstract Buccal midazolam was used to treat 40 seizures in 14 students and rectal diazepam 39 seizures in 14 students. Midazolam stopped 30 (75%) of 40 seizures and diazepam 23 (59%) of 39 (p=0.16). The median time from arrival of the nurse to administration of medication was 2 min. Time from administration to end of seizure did not differ significantly between the two treatments. No clinically important adverse cardiorespiratory events were identified in the two groups. Buccal midazolam was universally acceptable to the nursing and care staff. Buccal midazolam is at least as effective as rectal diazepam in the acute treatment of seizures. Administration via the mouth is more socially acceptable and convenient and may become the preferred treatment for long seizures that occur outside the hospital.

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