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A review of literature referable to management issues for women with epilepsy (WWE) was undertaken for the development of practice parameter. Pregnancy outcome literature for WWE spans several decades. Methodology varies and interpretation is complicated by modern management strategies. Contributions of socioeconomic factors, AEDs, maternal epilepsy, and seizures during pregnancy to adverse pregnancy outcomes have not been clearly delineated. There is a biologic basis for recommendations concerning contraception, folate supplementation, vitamin K use in pregnancy, breast-feeding, metabolic bone disease, catamenial epilepsy, and reproductive endocrine disorders, but no outcome studies afford a strong evidence base for practice recommendation. WWE face health issues for which there is no available outcome literature to guide decision making. The urgent need for studies in many of these areas is highlighted by expanded treatment options with new AEDs and epilepsy surgery. |
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anticonvulsants anticonvulsants,blood level determination of anticonvulsants,teratogenicity of anticonvulsants,untoward effects of breast feeding congenital birth defects congenital malformation developmental retardation folic acid menses,seizure with obstetric neurologic injuries oral contraceptives outcome research pregnancy,anticonvulsants during pregnancy,neurologic complications in review article seizure seizure,pregnancy seizure,treatment of seizure,women stillbirth teratogenesis treatment of neurologic disorder vitamin K vitamin supplementation
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