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To determine the incidence, risk factors, and long-term sequelae of the purple glove syndrome )PGS) in hospital patients receiving IV phenytoin. A total of 152 patients received IV phenytoin and 9 (5.9%) developed PGS. PGS patients received a greater median initial dose of phenytoin, total 24 hour dose, and total number of doses (all p < 0.05). In addition, the median age of the PSG patients was older, their infusion was more often given for seizures, it was less likely to be administered in the operating room, and the length of their hospital stay was longer (all p < 0.05). One patient required surgical therapy, and all other patients resolved within 3 weeks with conservative management. PGS is not rare and elderly patients and individuals receiving large, multiple doses are particularly at risk. The iatrogenic complication may be preventable by substituting fosphenytoin for IV phenytoin. |
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adverse drug reaction anticonvulsants,parenteral administration anticonvulsants,untoward effects of cost effectiveness dilantin dilantin,intravenous fosphenytoin iatrogenic neurologic disorders old age,neurology of purple glove syndrome purple hands risk factors seizure seizure,elderly seizure,treatment of
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