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Of 402 patients with PN, 93 (23.1%) had CSPN and stable to slowly progressive PN syndrome. These patients presented with a mean age of 63.2 years and a mean duration of symptoms of 62.9 months. Symptoms almost always started in the feet an d included distal numbness or tingling in 86% of patients and pain in 72% of patients. Despite the absence of motor symptoms at presentation, results of motor nerve conduction studies were abnormal in 60% of patients, and electromyographic evidence of de nervation was observed in 70% of patients. Results of laboratory studies were consistent with axonal degeneration. Patients with and without pain were similar regarding physical findings and laboratory test abnormalities. Only a few patients (<5%) had n o evidence of large-fiber dysfunction on physical examination or electrophysiologic studies. All 66 patients who had follow-up examinations (mean, 12.5 months) remained ambulatory. Cryptogenic sensory polyneuropathy is a common, slowly progressive neuro pathy that begins in late adulthood and causes limited motor impairment. Isolated small-fiber involvement is uncommon in this group of patients. Management should focus on rational pharmacotherapy of neuropathic pain combined with reassurance of CSPN's benign clinical course. |
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denervation potentials foot numbness idiopathic polyneuropathy nerve conduction studies nerve conduction studies,motor neurologic disease,diagnoses of neuropathy,idiopathic neuropathy,painful neuropathy,peripheral,treatment neuropathy,sensory neuropathy,work up for pain pain,management of chronic pain,neuropathic sensory loss sensory polyneuropathy sensory polyneuropathy,cryptogenic sensory testing,quantitative skin,biopsy treatment of neurologic disorder
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