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Initial Clinical Experience with IV Tissue Plasminogen Activator for Acute Ischemic Stroke:A Multicenter Survey Neurol 53:424-427, Tanne,D.,et al, 1999 See this aricle in Pubmed Article Abstract We assessed initial clinical experience with IV tissue plasminogen activator (t-PA) treatment of acute ischemic stroke in a standardized retrospective survey of hospitals with experienced acute stroke treatment systems. The incidence of symptomatic intracerebral hemorrhage (ICH) was 6% (11 of 189 patients; 95% CI 3 to 11%), similar to that in the National institute of Neurological Disorders and Stroke (NINDS) t-PA Stroke Study. Deviations from the NINDS protocol guidelines were identifi ed in 30% of patients with protocol deviations as compared with 4% in patients who were treated according to the NINDS protocol guidelines, suggesting that strict adherence to protocol guidelines is prudent.

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(click to filter results - removes previous filter) adverse drug reaction cerebrovascular accident cerebrovascular accident,acute management of cerebrovascular accident,thrombolytic agents in treatment fibrinolytic agents fibrinolytic agents,complications intracerebral hemorrhage practice guidelines tissue plasminogen activator,intravenous treatment of neurologic disorder

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