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The evidence-based data support adjunctive dexamethasone therapy for children with Haemophilus inflenzae meningitis. However, the optimal duration of therapy is not defined. Data are supportive but not conclusive that dexamethasone benef its meningitis caused by other bacterial agents and meningitis in adults. The evidence-based data are supportive but not conclusive that adjunctive glucocorticoid therapy benefits patients with tuberculous meningitis, particularly those with more sever i nfection. Although adjunctive glucocorticoid therapy may be beneficial in both acute bacterial meningitis and more severe tuberculous meningitis, there are conclusive data only for H influenzae meningitis in children. For acute bacterial meningitis, fu rther studies are needed to clarify the optimal duration of dexamethasone therapy (2 vs 4 days), whether this therapy would be used routinely for adults with meningitis, and whether it should be used for pathogens other than H influenzae. For tuberculous meningitis, further studies are needed to provide conclusive evidence of benefit. |
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bacterial infection
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controversies in neurology
meningitis
meningitis,bacterial
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meningitis,TB
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review article
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