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The Clinical Relevance of the Interaction Between Carbamazepine and Dextropropoxyphene in Elderly Patients in Gotenburg, Sweden Europ J Clin Pharm 53:203-206, Bergendal,L.,et al, 1997 See this aricle in Pubmed Article Abstract The doses of CBZ and dextropopoxyphene were lower among patients who used the combination of the two drugs than among those who only used on of the drugs. The mean level of CBZ in serum (S-CBZ) was, however, significantly higher and the lev el of CBZ-E in serum (S-CBZ-E) significantly lower among the patients who used the combination of CBZ and dextropropoxyphene, thus indicating an inhibition of the metabolism of CBZ. The prevalence of symptoms indicating side effects of CBZ was significan tly higher in the group of patients who used both drugs. This study has shown that the combination of CBZ and dextropropoxyphene is hazardous in elderly patients and should be used with caution.

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(click to filter results - removes previous filter) carbamazepine carbamazepine,toxicity drug interactions old age,neurology of propoxyphene

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