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Pathologic Heterogeneity in Clinically Diagnosed Corticobasal Degeneration
Neurol 53:795-800, Boeve,B.F.,et al, 1999
See this aricle in Pubmed

Article Abstract
Thirteen cases were identified. The pathologic diagnoses were CBD in seven, AD in two, and one each for progressive supranuclear palsy, Pick's disease, nonspecific degenerative changes, and Creutzfeldt-Jakob disease. Two cases had neglig ible basal ganglia and nigral degeneration despite previously having obvious extrapyramidal signs. However, all patients had focal or asymmetric cortical atrophy with coexisting neuronal loss and gliosis with or without status spongiosis, which was maxim al in the parietal and frontal cortical regions. The constellation of clinical features considered characteristic of CBD is associated with heterogeneous pathologies. Furthermore, this syndrome can occur in the absence of basal ganglia and nigral degene ration. The one invariable pathologic abnormality in patients with this syndrome, however, is asymmetric parietofrontal cortical degeneration. At present, accurate diagnosis of CBD requires tissue examination.
 
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apraxia
cortical-basal ganglionic degeneration
degenerative diseases of CNS
imbalance,postural
misdiagnosis
neurologic signs
neuropathology
neuropathology,brain
rigidity

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