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Diversity in Presenting Manifestations of Systemic Lupus Erythematosus in Children
J Pediatr 135:500-505, Iqbal,S.,et al, 1999
See this aricle in Pubmed

Article Abstract
Median age at onset was 12 years. The male to female ratio was 1:18.5, and racial/ethnic backgrounds were white 41%, black 33%, and Hispanic 26%. Initial manifestations included musculoskeletal 74%, cutaneous 72%, constitutional 67%, neur ologic 28%, renal 28%, lymphadenopathy 15%, and Raynaud's phenomenon 10%. Laboratory abnormalities at presentation to our clinic included elevated erythrocyte sedimentation rate 87%, anemia 72%, lymphopenia 59%, leukopenia 31%, proteinuria or cellular ca sts 44%, low C-sub3 or C-sub4 level 77%, antinuclear antibodies 97%, and anti-double-stranded DNA 95%. One third (33%) presented with features not initially suggestive of SLE. Six patients presented with unusual manifestations including parotitis, quadr iplegia, chorea, severe abdominal pain, persistent cough, and dizziness. However, 85% of patients with atypical manifestations had abnormal complete blood count or urinalysis results a presentation. Presenting manifestations of SLE in children are diver se. A detailed history, thorough review of systems, complete physical examination, complete blood count, urinalysis, and high index of suspicion help to make the correct diagnosis of SLE in patients with atypical presentations.
 
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