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Takayasu Arteritis
Ann Int Med 120:919-929, Kerr,G.S.,et al, 1994
See this aricle in Pubmed

Article Abstract
In our series of patients. Takyasu arteritis was more common in Asian persons compared with persons from other racial groups. Females (97%) were most frequently affected. The median age at disease onset was 25 years. Juveniles had a de lay in diagnosis that was about four times that of adults. The clinical presentation ranged from asymptomatic to catastrophic with stroke. The most common clinical finding was a bruit. Hypertension was most often associated with renal artery stenosis. Only 33% of all patients had systemic symptoms on presentation. Sixty-eight percent of patients had extensive vascular disease; stenotic lesions were 3.6-fold more common than were aneurysm (98% compared with 27%). The erythrocyte sedimentation rate wa s not a consistently reliable surrogate marker of disease activity. Surgical bypass biopsy specimens from clinically inactive patients showed histologically active disease in 44% of patients. Although clinically significant palliation usually occurred a fter angioplasty or bypass of severely stenotic vessels, restenosis was common. Medical therapy was required for 80% of patients, whereas 20% had monophasic self-limiting disease. Immunosuppressive treatment with glucocorticoids alone or in combination with a cytotoxic agent failed to induce remission in one fourth of patients; about half of those who achieved remission later relapsed.
 
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aneurysm,abdominal aortic
aneurysm,thoracic aortic
arteritides
bruit
bruit,abdominal
bruit,supraclavicular
carotidynia
cerebrovascular accident,women
cerebrovascular accident,young adult
claudication,extremity
delay in diagnosis
disability,neurological
dizziness
parietal lobe,lesion of
pathology
peripheral pulse,absent
pregnancy,neurologic complications in
prognosis
review article
sedimentation rate
Takayasu's arteritis
vertebral artery stenosis

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