Click Here to return To Results

 

Incidence and Prevalence of Neurological Disorders Associated with HIV Since the Introduction of Highly Active Antiretroviral Therapy (HAART) JNNP 69:376-380, Maschke,M. et al, 2000 See this aricle in Pubmed Article Abstract Significantly more patients received HAART in 1997-8 (p<0.001) and mean CD4+ cell count was significantly higher in 1997-8 (p<0.001). The prevalence of HIV associated dementia and HIV associated polyneuropathy were significantly lower in 1997-8 (both: p=0.02) and the incidence of toxoplasma encephalitis decreased from 5.7% in 1995-6 to 2.2% in 1997-8 (p=0.015). Based on the small number of patients significant changes in HIV associated myopathy, progressive multifocal leukoencephalopathy, cryptococal meningitis, and cytomegalovirusencephalitis could not be detected. The prevalence of the most frequent HIV associated neurological disorders and incidence of toxoplasma encephalitis decreased since the introduction of HAART. This may be due to the improvement of immunostatus by HAART as demonstrated by the higher CD4+ cell count in the later time interval. Direct antiretroviral effects within the nervous system may be considered causative as well. The prevalence and incidence of HIV associated neurological disorders and opportunistic CNS infections decreased after introduction of HAART.

Related Tags

(click to filter results - removes previous filter) acquired immunodeficiency syndrome acquired immunodeficiency syndrome dementia complex antiviral agents CD4 counts dementia highly active antiretroviral therapy human immunodeficiency virus type 1 myopathy neurologic disease neuropathy opportunistic infection opportunistic infection,CNS prevention of neurologic disorders prognosis protease inhibitor,HIV-1 toxoplasmosis,CNS treatment of neurologic disorder viral infection,CNS

Click Here to return To Results