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Autoantibodies to Ganglionic Acetylcholine Receptors in Autoimmune Autonomic Neuropathies NEJM 343:847-855, Verning,S. et al, 2000 See this aricle in Pubmed Article Abstract Ganglionic-receptor-binding antibodies were found in 19 of 46 patients with idiopathic or paraneoplastic autonomic neuropathy (41 percent), in 6 of 67 patients with postural tachycardia syndrome, idiopathic gastrointestinal dysmotility, or diabetic autonomic neuropathy (9 percent), and in non of 44 patients with other autonomic disorders. High levels of the binding antibodies correlated with more severe autonomic dysfunction (including the presence of tonic pupils). Levels of these antibodies decreased in patients who had clinical improvement. All seven patients with ganglionic-receptor-blocking antibodies had ganglionic-receptor-binding antibodies and had idiopathic or paraneoplastic autonomic neuropathy. Seropositivity for antibodies that bind to or block ganglionic acetylcholine receptor identifies patients with various forms of autoimmune autonomic neuropathy and distinguishes these disorders from other types of dysautonomia. The positive correlation between high levels of ganglionic-receptor antibodies and the severity of autonomic dysfunction suggests that the antibodies have a pathogenic role in these types of neuropathy.

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(click to filter results - removes previous filter) acetylcholine receptor antibody acetylcholine receptor antibody,ganglionic autoantibodies autoimmune disease autonomic dysfunction autonomic neuropathy autonomic neuropathy,idiopathic neuropathy neuropathy,etiologies of

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