Click Here to return To Results

 

Misleading Results With the 14-3-3 Assay for the Diagnosis of Creutzfeldt-Jakob Disease Neurol 55:1396-1397, Chapman,T.,et al, 2000 See this aricle in Pubmed Article Abstract The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe th ree patients for whom CSF 14-3-3 assays were falsely positive of falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.

Related Tags

(click to filter results - removes previous filter) dementia,rapidly progressive Jakob-Creutzfeldt disease misdiagnosis protein 14-3-3,cerebrospinal fluid protein 14-3-3,cerebrospinal fluid,false negative protein 14-3-3,cerebrospinal fluid,false positive

Click Here to return To Results