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Indomethacin Reduces CSF Pressure in Intracranial Hypertension
Neurol 55:1043-1045, Forderreuther,S. & Straube,A., 2000
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Article Abstract
The CSF-pressure-lowering effects of indomethacin in seven patients with idiopathic intracranial hypertension and one patient with symptomatic intracranial hypertension due to a non-space-occupying meningioma are reported. CSF opening press ure between 350 and 500 mm H20 (mean 400 mm H20) was promptly reduced by 80 to 200 mm H2) (mean reduction, 139 mm H20) for at least 10 minutes in all patients after IV administration of 50 mg indomethacin. Four patients had mild and transient side effect s (dizziness). Indomethacin might be an alternative drug for treatment of intracranial hypertension.
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indomethacin
intracranial hypertension,benign
intracranial pressure,increased
treatment of neurologic disorder
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