Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Safety of Discontinuation of Anticoagulation in Patients with Intracranial Hemorrhage at High Thromboembolic Risk
Arch Neurol 57:1710-1713,1682, Phan,T.G.,et al, 2000
See this aricle in Pubmed

Article Abstract
The indications for anticoagulation were a prosthetic heart valve (52 patients [group 1], atrial fibrillation and cardioembolic stroke (53 patients [group 2]), and a recurrent transient ischemic attack or an ischemic stroke (36 patients [gro up3]). A prior ischemic stroke occurred in 14 (27%) of group 1 patients and in 23 (43%) of group 2 patients. Death occurred in 43% of the 141 patients. The median time not taking warfarin in this cohort was 10 days. Three patients had an ischemic stro ke within 30 days of warfarin therapy discontinuation. Using Kaplan-Meier survival estimates, the probability of having an ischemic stroke at 30 days following warfarin therapy cessation in groups 1, 2, and 3 was 2.9% (95% confidence interval, 0%-8.0%), 2.6% (95% confidence interval, 0%-7.6%), and 4.8% (95% confidence interval, 0%-13.6%), respectively. In the 35 patients who had warfarin therapy restarted, none had recurrence of ICH during the same hospitalization. Discontinuation of warfarin therapy f or 1 to 2 weeks has a comparatively low probability of embolic events in patients at high embolic risk. This should be taken into consideration when deciding whether to continue or discontinue anticoagulation in these patients at high embolic risk. Earl y recurrence of ICH is exceedingly uncommon.
 
Related Tags
(click to filter results - removes previous filter)

adverse drug reaction
anticoagulant,complications of
anticoagulant,discontinuation
anticoagulant,reversal of
anticoagulant,treatment
anticoagulant,treatment in CVD
coumarin
intracerebral hemorrhage
intracranial hemorrhage
review article
treatment of neurologic disorder

Click Here to return To Results