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Functional Correlates of Pallidal Stimulation for Parkinson's Disease Ann Neurol 49:155-164,142, Fukuda,M.,et al, 2001 See this aricle in Pubmed Article Abstract We measured regional cerebral blood flow with H215O and positron emission tomography (PET) scanning at rest and during a motor task to study the mechanism of motor improvement induced by deep brain stimulation of the internal globus pallidus in Parkinson's disease. With internal globus pallidus deep brain stimulation, improved movement initiation correlated with regional cerebral blood flow increases in the left sensorimotor cortex and ventrolateral thalamus and in the contralateral cerebel lum. By contrast, improved spatial accuracy correlated with regional cerebral blood flow increases in both cerebellar hemispheres and in the left sensorimotor cortex. These results suggest that internal globus pallidus deep brain stimulation may selecti vely improve different aspects of motor performance. Multiple, overlapping neural pathways may be modulated by this intervention.

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(click to filter results - removes previous filter) CAT scan,emission globus pallidus,stimulation MRI,functional Parkinson disease stimulation,deep brain

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