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Randomized Controlled Trial of Intravenous Immunoglobulin Versus Oral Prednisolone in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Ann Neurol 50:195-201, Hughes,R.,et al, 2001 See this aricle in Pubmed Article Abstract Both treatments produced significant improvements in the primary outcome measure, change in an 11-point disability scale two weeks after randomization. There was slightly, but not significantly, more improvement after IVIg than with prednis olone, the mean difference between the groups in change in disability grade being 0.16 (95% CI = -0.35 go 0.66). There were also slightly, but not significantly, greater improvements favoring IVIg in the secondary outcome measures: time to walk 10 meters after two weeks and improvement in disability grade after six weeks. Results may have been biased against IVIg by the eight patients who did not complete the second arm of the trial. A serious adverse event (psychosis) attributable to treatment occurre d in one patient while on prednisolone and in none with IVIg.

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(click to filter results - removes previous filter) gammaglobulin therapy,intravenous polyneuropathy,chronic inflammatory demyelinating steroid steroid therapy,CNS treatment and complications with treatment of neurologic disorder

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