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14-3-3 Protein in the CSF as Prognostic Marker in Early Multiple Sclerosis Neurol 57:722-724, Martinez-Yelamos,A.,et al, 2001 See this aricle in Pubmed Article Abstract Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1:95% CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) >/=2 at the end of follow-up (odds ratio 14.8; 95% ci 2.86 TO 76.8). Th e Detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution.

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(click to filter results - removes previous filter) axonal degeneration cerebrospinal fluid cerebrospinal fluid,abnormal cerebrospinal fluid,protein of fourth ventricle,shift of multiple sclerosis multiple sclerosis,diagnosis of multiple sclerosis,monosymptomatic protein 14-3-3,cerebrospinal fluid

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