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Diphtheritic Polyneuropathy,Clinical Analysis of Severe Forms Arch Neurol 58:1438-1442, Piradov,M.A.,et al, 2001 See this aricle in Pubmed Article Abstract A direct indication for tracheotomy and artificial ventilation in patients with DP is a decrease of the vital capacity of the lungs below the traditional 16 mL/kg body weight or the development of the paralytic closure of the larynx against t he background of the increasing weakness of the respiratory muscles. Characteristic of severe forms of DP is the phenomenon of the oppositely directed change in the neurological symptoms in the second month of the disease: the restoration of the function of the cranial nerves against the background of the further increase of the motor disturbances in the extremities and trunk. Special attention and care should be taken of patients during the period of the appearance of the episodes of vascular collapses - between the fourth and seventh weeks of DP.

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