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Lack of Clinical Significance of Early Ischemic Changes on Computed Tomography in Acute Stroke JAMA 286:2830-2838, Patel,S.C.,et al, 2001 See this aricle in Pubmed Article Abstract The prevalence and clinical significance of early ischemic changes (EICs) on baseline computed tomography (CT) scan of the head obtained within 3 hours of ischemic stroke are not established. Our analysis suggests that EICs are prevalent wi thin 3 hours of stroke onset and correlate with stroke severity. However, EICs are not independently associated with increased risk of adverse outcome after rt-PA treatment. Patients treated with rt-PA did better whether or not they had EICs, suggesting that EICs on CT scan are not critical to the decision to treat otherwise eligible patients with rt-PA within 3 hours of stroke onset.

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