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Diffusion-perfusion MRI Characterization of Post-recanalization Hyperperfusion in Humans Neurol 57:2015-2021, Kidwell,C.S.,et al, 2001 See this aricle in Pubmed Article Abstract Postischemic hyperperfusion, visualized with perfusion MRI in humans following recanalization by intra-arterial thrombolytic therapy, occurred in about 40% of patients within hours and in about 50% of patients at day 7. Hyperperfusion devel oped mainly in regions that went on to infarction. Compared with other abnormal regions, tissues that developed postischemic hyperperfusion had greater bioenergetic compromise in pretreatment apparent diffusion coefficient values and greater impairment i n pretreatment blood flow measures.

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