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Parneoplastic chorea is described in 16 patients: 11 with limited small-cell carcinoma, 2 with lung cancer revealed by imaging, 1 with renal cell carcinoma, and 1 with lymphoma. All had CRMP-5-IgG; 6 also had ANNA-1 (anti-Hu), including 1 w ithout evident cancer. Chorea was the initial and most prominent symptom in 11 patients, asymmetric or unilateral in 5 patients, and part of a multifocal syndrome in 14 patients. Basal ganglia abnormalities were revealed by magnetic resonance imaging an d at autopsy (as perivascular inflammation and microglial activation). Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone. |
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anosmia anti Hu antibody autoantibodies basal ganglia basal ganglia,lesion of basal ganglia,lesion,bilateral carcinoma carcinoma of lung chemotherapy,CNS treatment and complications with chorea chorea,causes of collapsin response mediator protein 5 IgG encephalitis hemichorea limbic encephalitis lymphoma lymphoma involving CNS movement disorder MRI MRI,abnormal MRI,disappearing lesion on remote effect of cancer on the nervous system renal cell carcinoma smell steroid therapy,CNS treatment and complications with striatal encephalitis striatum,lesion of striatum,lesion of,bilateral treatment of neurologic disorder
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