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Cranial MR Findings in Chronic Toluene Abuse by Inhalation AJNR 23:1173-1179,1072, Aydin, K.,et al, 2002 See this aricle in Pubmed Article Abstract White matter changes seem to start in the deep periventricular white matter, and they spread into peripheral white matter, causing the loss of gray matter-white matter differentiation with continued toluene abuse. The deposition of iron due to demyelination and axonal loss is the most probable mechanism for the thalamic hypointensity found in solvent abusers.

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