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Late Secondary Ischemic Injury in Patients Receiving Intraarterial Thrombolysis Ann Neurol 52:698-703,695, Kidwell,C.S.,et al, 2002 See this aricle in Pubmed Article Abstract Among the eight patients with early diffusion imaging reversal, late secondary injury by day 7 occurred in 5 (63%), and sustained normalization of all reversed tissue occurred in 3 (38%). Pretreatment apparent diffusion coefficient values w ere lowest in regions experiencing no reversal (mean apparent diffusion coefficient, 608 ¦m2/sec), intermediate in regions with reversal and secondary decline (617 ¦m2/sec), and highest in regions with sustained reversal (663 ¦m2/sec). There was a trend toward less improvement in neurological deficit in patients with secondary injury versus patients with sustained reversal. In the future, late secondary tissue injury may become an important therapeutic target for postreperfusion neuroprotective therapie s, with treatment efficacy monitored by serial diffusion magnetic resonance imaging.

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(click to filter results - removes previous filter) cerebrovascular accident,thrombolytic agents in treatment fibrinolytic agents,complications fibrinolytic agents,intra-arterial local infusion iatrogenic neurologic disorders MRI MRI,abnormal MRI,ADC maps MRI,diffusion weighted MRI,mismatch between perfusion/diffusion MRI,serial recanalization,arterial

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