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In the recently proposed diagnostic criteria for multiple sclerosis (MS) by McDonald, the modified magnetic resonance imaging (MRI) Barkhof criteria have been incorporated. We examined the validity of this implementation in the Early Treatment of MS study, a randomized, double-blind, placebo-controlled study of 22?g interferon B1a given subcutaneously once weekly in 309 patients with a first episode consistent with demyelinating disease ( and abnormal MRI). Treatment effect seemed more evident as the number of positive criteria increased, and the number of patients needed to avoid one patient converting to CDMS decreased from 50 in patients with one or two positive criteria to 5.6 in patients with four positive criteria. However, the study was not powered to detect statistically significant treatment by variable interaction, and this remains an important issue for further study. |
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Barkhof MR criteria for MS
interferon beta 1-a
MRI
MRI,abnormal
MRI,demyelinating disease
multiple sclerosis
multiple sclerosis,diagnostic criteria
multiple sclerosis,treatment of
multiple sclerosis,treatment of,first attack
treatment of neurologic disorder
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