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Antimyelin Antibodies as a Predictor of Clinically Definite Multiple Sclerosis After a First Demyelinating Event NEJM 349:139-145,107, Berger,T.,et al, 2003 See this aricle in Pubmed Article Abstract Most patients with multiple sclerosis initially present with a clinically isolated syndrome. Despite the fact that clinically definite multiple sclerosis will develop in up to 80 percent of these patients, the course of the disease is unpredictable at its onset and requires long-term observation or repeated magnetic resonance imaging (MRI). We investigated whether the presence of serum antibodies against myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) in patients with a clinically isolated syndrome predicts the interval to conversion to clinically definite multiple sclerosis. Analysis of antibodies against MOG and MBP in patients with a clinically isolated syndrome is a rapid, inexpensive, and precise method for the prediction of early conversion to clinically definite multiple sclerosis. This finding may be important for the counseling and care of patients with a first demyelinating even suggestive of multiple sclerosis.

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(click to filter results - removes previous filter) anti MAG antibodies antibodies to myelin basic protein antimyelin antibodies MRI MRI,abnormal multiple sclerosis multiple sclerosis,clinical patterns multiple sclerosis,diagnosis of multiple sclerosis,monosymptomatic multiple sclerosis,prognosis neurologic disease,diagnoses of prognosis serologic testing

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