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Neurotoxicity Following Addition of Intravenous Valproate to Lamotrigine Therapy
Neurol 60:1991-1992, Burneo,J.G.,et al, 2003
See this aricle in Pubmed

Article Abstract
Reversible neurotoxic symptoms were observed in three adult patients with absence status epilepticus on lamotrigine (LTG) therapy after administration of an IV bolus followed by oral valproic acid (VPA). Neurotoxicity was likely related to elevated serum LTG levels, as improvement correlated with discontinuing or reducing LTG dosage.
 
Related Tags
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adverse drug reaction
anticonvulsants
anticonvulsants,untoward effects of
drug interactions
lamotrigine
neurotoxin
sodium valproate
sodium valproate,intravenous
status epilepticus,nonconvulsive

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