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Biochemical And Clinical Aspects of Methotrexate Neurotoxicity
Chemotherapy 49:92-104, Vezmar,S.,et al, 2003
See this aricle in Pubmed

Article Abstract
Acute, subacute and chronic neurotoxicity have been observed after the administration of high-dose and/or intrathecal methotrexate (MTX). Acute toxicity is usually transient without permanent damage. Subacute and chronic toxicity are associated with changes in the brain and/or the spinal cord which may be progressive and even lead to coma and death in severe cases. It is believed that MTX can induce direct toxic effects to the CNS by damaging the neuronal tissue.
 
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ataxia
chemotherapy,CNS treatment and complications with
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