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Randomized, Concentration-Controlled Trial of Topiramate in Refractory Focal Epilepsy Neurol 61:1210-1218, Christensen,J.,et al, 2003 See this aricle in Pubmed Article Abstract Patients assigned to the medium plasma level (31 umol/L [10.5 mg/L]) had the best seizure outcome. Patient sin the medium and high groups experienced more adverse events than patients in the low group. Optimal treatment response is thus most likely found a plasma concentrations higher than 6 ?mol/L (2 mg/L), but no further increase in efficacy seems to occur at concentrations above 31 ?mol/L (10.5 mg/L).

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(click to filter results - removes previous filter) anticonvulsants,blood level determination of anticonvulsants,effectiveness efficacy seizure seizure,focal seizure,intractable seizure,intractable,treatment of seizure,treatment of topiramate treatment of neurologic disorder

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