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Comparison of Different MRI Brain Atrophy Rate Measures with Clinical Disease Progression in AD
Neurol 62:591-600, Jack, Jr.,C.R.,et al, 2004
See this aricle in Pubmed

Article Abstract
These data support the use of rates of change from serial MRI studies in addition to standard clinical/psychometric measures as surrogate markers of disease progression in AD. Estimated sample sizes required to power a therapeutic trial in MCI were an order of magnitude les for MRI than for change measures based on cognitive tests/rating scales.
 
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Alzheimer's disease
brain atrophy
cerebral cortical atrophy
hippocampus
mild cognitive impairment
MRI
MRI,abnormal
MRI,serial
ventricular enlargement

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