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Are There Time-Dependent Differences in Diffusion and Perfusion Within the First 6 Hours After Stroke Onset? Stroke 35:2099, Fiehler,J.,et al, 2004 See this aricle in Pubmed Article Abstract We observed no significant time-dependent differences within 6 hours after stroke onset in degree and volume of diffusion and perfusion impairment. An exclusion from intravenous tPA solely based on a rigid 3-hour time window seems unjustified in MRI-confirmed ischemic stroke.

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