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We retrospectively studied 82 patients (65 women and 17 men) with neurologic manifestations associated with primary SS, as defined by the 2002 American-European criteria. The mean age at neurologic onset was 53 years. Neurologic involvement frequently preceded the diagnosis of SS (81% of patients). Fifty-six patients had CNS disorders, which were mostly focal or multifocal. Twenty-nine patients had spinal cord involvement (acute myelopathy [n = 12], chronic myelopathy [n = 16], or motor neuron disease [n = 1]). Thirty-three patients had brain involvement and 13 patients had optic neuropathy. The disease mimicked relapsing-remitting multiple sclerosis (MS) in 10 patients and primary progressive MS in 13 patients. We also recorded diffuse CNS symptoms: some of the patients presented seizures (n = 7), dysfunction (n = 9), and encephalopathy (n = 2). Fifty-one patients had peripheral nervous system involvement (PNS). Symmetric axonal sensorimotor polyneuropathy with a predominance of sensory symptoms or pure sensory neuropathy occurred most frequently (n = 28), followed by cranial nerve involvement affecting trigeminal, facial, or cochlear nerves (n = 16). Multiple mononeuropathy (n = 7), myositis (n = 2), and polyradiculoneuropathy (n = 1) were also observed. Thirty percent of patients (all with CSN involvement) had oligoclonal bands. |
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ANA
autoantibodies
Barkhof MR criteria for MS
basal ganglia
basal ganglia,lesion of
cerebrospinal fluid,oligoclonal IgG in
cerebrovascular accident,mimics
cranial neuropathy
cyclophosphamide
encephalitis
encephalitis,recurrent
hearing loss
mimics
misdiagnosis
mononeuropathy
MRI
MRI,abnormal
MRI,spinal cord
multiple sclerosis,misdiagnosis
myelopathy
myelopathy,chronic progressive
myositis
neurologic disease,diagnoses of
neuropathy
neuropathy,sensory
optic neuritis
optic neuropathy
pleocytosis of cerebrospinal fluid
prognosis
recurrent
review article
seizure
Sjogren's syndrome
Sjogren's syndrome,neurologic manifestations of
strokelike episodes
treatment of neurologic disorder
xerophthalmia
xerostomia
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