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Homocysteine and Stroke: Evidence on a Causal Link From Mendelian Randomisation
Lancet 365:224-232, 194, Casas, J.P., et al, 2005
See this aricle in Pubmed

Article Abstract
The observed increase in risk of stroke among individuals homozygous for the MTHFR T allele is close to that predicted from the differences in homocysteine concentration conferred by this variant. This concordance is consistent with a causal relation between homocysteine concentration and stroke.
 
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