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MGMT Gene Silencing and Benefit From Temozolomide in Glioblastoma
NEJM 352:997-1003, 1036, Hegi,M.E., et al, 2005
See this aricle in Pubmed
Article Abstract
Patients with glioblastoma containing a methylated MGMT promotor benefited from temozolomide, whereas those who did not have a methylated MGMT promotor did not have such a benefit.
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advances in neurology
alkylating agents
chemotherapy,CNS treatment and complications with
glioblastoma multiforme(astrocytoma Gr.III)
neoplasm,primary of CNS
neoplasm,primary of CNS-treatment of
temozolomide
treatment of neurologic disorder
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