Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Autoantibodies to Folate Receptors in the Cerebral Folate Deficiency Syndrome
NEJM 352:1985-1991, Ramaekers,V.T.,et al, 2005
See this aricle in Pubmed

Article Abstract
In infantile-onset cerebral folate deficiency, 5-methyltetrahydrofolate (5MTHF) levels in the cerebrospinal fluid are low, but folate levels in the serum and erythrocytes are normal. We examined serum specimens from 28 children with cerebral folate deficiency, 5 of their mothers, 28 age-matched control subjects, and 41 patients with an unrelated neurologic disorder. Serum from 25 of the 28 patients and 0 of 28 control subjects contained high-affinity blocking autoantibodies against membrane-bound folate receptors that are present on the choroids plexus. Oral folinic acid normalized 5MTHF levels in the cerebrospinal fluid and led to clinical improvement. Cerebral folate deficiency is a disorder in which autoantibodies can prevent the transfer of folate from the plasma to the cerebrospinal fluid.
 
Related Tags
(click to filter results - removes previous filter)

ataxia
ataxia,cerebellar
autoantibodies
ballismus,bilateral
blindness
cerebral folate deficiency syndrome
cerebrospinal fluid,abnormal
children
choreoathetosis
choroid plexus
dyskinesia
folic acid
folic acid deficiency
irritability
optic atrophy
psychomotor retardation
pyramidal tract dysfunction
seizure
treatment of neurologic disorder

Click Here to return To Results