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Linezolid-Associated Toxic Optic Neuropathy Neurol 66:595-598, Rucker,J.C.,et al, 2006 See this aricle in Pubmed Article Abstract The oxazolidinone antimicrobial linezolid is effective against gram-positive bacteria. Although maximal recommended therapy is 28 days, treatment durations greater than this are common. Linezolid may cause reversible optic neuropathy and irreversible peripheral neuropathy after months of treatment. Three cases of linezolid-induced optic and peripheral neuropathy are described, and previously reported cases of linezolid-induced optic neuropathy are reviewed. The mechanism of neural toxicity may be impairment of mitochondrial protein synthesis.

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(click to filter results - removes previous filter) adverse drug reaction antibiotics antibiotics,neurologic complications with linezolid neuropathy neuropathy,toxic neurotoxin optic neuropathy optic neuropathy,toxic vision,blurred visual loss

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