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Prophylactic Cranial Irradiation in Extensive Small-Cell Lung Cancer NEJM 356:664-672, Slotman,B.,et al, 2007 See this aricle in Pubmed Article Abstract Prophylactic cranial irradiation reduces the incidence of symptomatic brain metastases and prolongs disease-free and overall survival. (ClinicalTrials.gov number, NCT00016211).

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